Given that cholesterol is biosynthesized in the early morning hours, the US Food and Drug Administration (FDA) has recommended evening administration for statins with shorter half-lives (lovastatin 2 hours, simvastatin < 5 hours, and fluvastatin < 3 hours).
Statins you can take in the morning. Studies show that some of the newer statins can be just as effective when taken in the morning. HMG-CoA reductase inhibitors such as atorvastatin and rosuvastatin are more potent than older statins. They have half-lives of at least 14 hours.
Oct 04, 2003 · Taking simvastatin in the morning compared with in the evening: randomised controlled trial. Doubt has been cast on whether statins need to be taken at night, 4 particularly as many patients also receive treatment with other cardioprotective drugs and …
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Clinicians should therefore be aware that not all statins have similar pharmacodynamic and pharmacokinetic properties, and many statins can achieve equal LDL-lowering efficacy (and arguably improved compliance) when administered in the morning as compared with the evening.
So I’d like to know if it would be okay for me to take Zocor in the morning with my other pills, which I never forget. A. Many people have trouble remembering to take medications; drugs that are administered several times during the day are particularly troublesome.
Endogenous cholesterol synthesis is cyclical in nature with the greatest production during fasting states. The elimination half-lives of statins determine if an agent should be dosed at bedtime. To maximize the effects of statins with a short half-life, fluvastatin, lovastatin,
If you remember that cholesterol is manufactured in the liver at night it make sense to take the statins in the evening. Also many patients on statins are taking an aspirin a day which also seems to be better taken at bedtime. If a statin is taken in the morning it still works but just not as well.
the rate of cholesterol synthesis in the liver shows diurnal periodicity, with production peaking at nighttime statins act by inhibiting the enzyme HMG CoA reductase, which controls synthesis of cholesterol in the liver. Most manufacturers of statins recommend that they are taken at night,
Oct 02, 2003 · Participants, methods, and results. Change in blood lipids was normally distributed and switching taking simvastatin from in the evening to in the morning resulted in statistically significant increases in total and low density lipoprotein cholesterol ( table ). Compliance did not differ between the groups (mean number of tablets 1, standard deviation 5 for both groups; P = 0.9).
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In general, there are a few statin medications that are usually fine to take at any time of the day due to how long they last in the body. They are Lipitor (atorvastatin), Crestor (Rosuvastatin) Pravachol (Pravastatin) and Livalo (Pitavastatin). They seem to be effective no matter what time of day you take …
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Statins you can take in the morning Studies show that some of the newer statins can be just as effective when taken in the morning. HMG-CoA reductase inhibitors such as atorvastatin and rosuvastatin are more potent than older statins.